| First Author | Ball AR Jr | Year | 2014 |
| Journal | Biochim Biophys Acta | Volume | 1839 |
| Issue | 3 | Pages | 191-202 |
| PubMed ID | 24269489 | Mgi Jnum | J:210866 |
| Mgi Id | MGI:5571993 | Doi | 10.1016/j.bbagrm.2013.11.002 |
| Citation | Ball AR Jr, et al. (2014) Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies. Biochim Biophys Acta 1839(3):191-202 |
| abstractText | Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called "cohesinopathies," reveal crucial roles for cohesins in development and cellular growth and differentiation. In this review, we discuss the latest findings concerning cohesin's functions in higher-order chromatin architecture organization and gene regulation and new insight gained from studies of cohesinopathies. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development. |
