| Primary Identifier | MGI:1351500 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 18226 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and PTB domain binding activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell population proliferation; and negative regulation of epidermal growth factor receptor signaling pathway. Acts upstream of or within cellular senescence. Located in nuclear membrane. Part of nuclear pore. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62). PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
