| Type | MGI:General | Description | chow-fed male (but not female) homozygotes display enhanced insulin sensitivity in insulin tolerance tests; insulin sensitivity remains elevated on a high-fat diet homozygotes show enhanced insulin sensitivity in hyperinsulinemic-euglycemic clamp studies, as shown by notable increases in rates of whole-body glucose disposal, glycolysis, and nonoxidative glucose metabolism interestingly, insulin sensitivity increases specifically in skeletal muscle, not in white adipose tissue |
