| Primary Identifier | MGI:1202395 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17394 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables endopeptidase activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of tumor necrosis factor production; and positive regulation of tumor necrosis factor-mediated signaling pathway. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and limb. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8). PHENOTYPE: Homozygous null males, and to a lesser extent ovariectomized or tamoxifen-treated null females, show increased susceptibility to chemically-induced skin tumors, a sustained inflammatory response to carcinogens, and increased PMN burden in the alveolar space during LPS-mediated acute lung injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
