| First Author | Chen ZF | Year | 1998 |
| Journal | Nat Genet | Volume | 20 |
| Issue | 2 | Pages | 136-42 |
| PubMed ID | 9771705 | Mgi Jnum | J:50169 |
| Mgi Id | MGI:1289984 | Doi | 10.1038/2431 |
| Citation | Chen ZF, et al. (1998) NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet 20(2):136-42 |
| abstractText | The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription from neuronal promoters in non-neuronal cell lines, but its function during normal development is unknown. In mice, a targeted mutation of Rest, the gene encoding NRSF, caused derepression of neuron-specific tubulin in a subset of non-neural tissues and embryonic lethality. Mosaic inhibition of NRSF in chicken embryos, using a dominant-negative form of NRSF, also caused derepression of neuronal tubulin, as well as of several other neuronal target genes, in both non-neural tissues and central nervous system neuronal progenitors. These results indicate that NRSF is required to repress neuronal gene expression in vivo, in both extra-neural and undifferentiated neural tissue. |
