Primary Identifier | IPR031169 | Type | Family |
Short Name | MIER1 |
description | MIER1 is a transcriptional regulator identified from a screen for fibroblast growth factor early response genes that are activated during mesoderm induction in Xenopus laevis embryos []. MIER1 has been shown to repress transcription using several distinct mechanisms [, ], including recruitment of histone deacetylase 1 (HDAC1) []. The protein consists of several isoforms with a common internal region and variable N- and C- termini []. The common region contains an ELM2 domain and a SANT domain, both of which play a role in transcriptional regulation [, ]. |