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Publication : Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity.

First Author  Hinckley CA Year  2015
Journal  Neuron Volume  87
Issue  5 Pages  1008-21
PubMed ID  26335645 Mgi Jnum  J:255024
Mgi Id  MGI:6113740 Doi  10.1016/j.neuron.2015.08.005
Citation  Hinckley CA, et al. (2015) Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity. Neuron 87(5):1008-21
abstractText  The coordination of multi-muscle movements originates in the circuitry that regulates the firing patterns of spinal motorneurons. Sensory neurons rely on the musculotopic organization of motorneurons to establish orderly connections, prompting us to examine whether the intraspinal circuitry that coordinates motor activity likewise uses cell position as an internal wiring reference. We generated a motorneuron-specific GCaMP6f mouse line and employed two-photon imaging to monitor the activity of lumbar motorneurons. We show that the central pattern generator neural network coordinately drives rhythmic columnar-specific motorneuron bursts at distinct phases of the locomotor cycle. Using multiple genetic strategies to perturb the subtype identity and orderly position of motorneurons, we found that neurons retained their rhythmic activity-but cell position was decoupled from the normal phasing pattern underlying flexion and extension. These findings suggest a hierarchical basis of motor circuit formation that relies on increasingly stringent matching of neuronal identity and position.
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