| First Author | Cardona AE | Year | 2008 |
| Journal | J Leukoc Biol | Volume | 84 |
| Issue | 3 | Pages | 587-94 |
| PubMed ID | 18467654 | Mgi Jnum | J:138114 |
| Mgi Id | MGI:3804327 | Doi | 10.1189/jlb.1107763 |
| Citation | Cardona AE, et al. (2008) Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. J Leukoc Biol 84(3):587-94 |
| abstractText | Actions of chemokines and the interaction with specific receptors go beyond their original, defined role of recruiting leukocytes to inflamed tissues. Chemokine receptor expression in peripheral elements and resident cells of the central nervous system (CNS) represents a relevant communication system during neuroinflammatory conditions. The following examples are described in this review: Chemokine receptors play important homeostatic properties by regulating levels of specific ligands in blood and tissues during healthy and pathological conditions; chemokines and their receptors are clearly involved in leukocyte extravasation and recruitment to the CNS, and current studies are directed toward understanding the interaction between chemokine receptors and matrix metalloproteinases in the process of blood brain barrier breakdown. We also propose novel functions of chemokine receptors during demyelination/remyelination, and developmental processes. |
