Primary Identifier | MGI:1346865 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 26416 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in mitochondrion; nucleus; and spindle pole. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and head mesenchyme. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). PHENOTYPE: Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation. [provided by MGI curators] |