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Protein Coding Gene : Nelfb negative elongation factor complex member B
Primary Identifier  MGI:1931035 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  58202
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable RNA binding activity. Involved in several processes, including negative regulation of stem cell differentiation; negative regulation of transcription elongation by RNA polymerase II; and stem cell differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of NELF complex. Is expressed in several structures, including blastocyst; early embryo; and gonad. Orthologous to human NELFB (negative elongation factor complex member B).
PHENOTYPE: Mice homozygous for a knock-out allele fail to develop inner cell masses and die between E5 and E13.5. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA A730008L03 gene,
  • Nelfb,
  • cofactor of BRCA1,
  • AB041607,
  • hypothetical protein, MNCb-5210,
  • negative elongation factor complex member B,
  • A730008L03Rik,
  • expressed sequence AI663983,
  • Cobra1,
  • MGI:2139041,
  • AI663983
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Features --> Cross References

Genome

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1 Transgenic Expressors

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

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Homology

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Interactions

9 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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