| First Author | Sanchis-Segura C | Year | 2009 |
| Journal | Front Behav Neurosci | Volume | 3 |
| Pages | 30 | PubMed ID | 19826619 |
| Mgi Jnum | J:223067 | Mgi Id | MGI:5647912 |
| Doi | 10.3389/neuro.08.030.2009 | Citation | Sanchis-Segura C, et al. (2009) Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues. Front Behav Neurosci 3:30 |
| abstractText | To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues. |
