| First Author | Gallahan D | Year | 1987 |
| Journal | J Virol | Volume | 61 |
| Issue | 1 | Pages | 218-20 |
| PubMed ID | 3023699 | Mgi Jnum | J:8496 |
| Mgi Id | MGI:56962 | Doi | 10.1128/jvi.61.1.218-220.1987 |
| Citation | Gallahan D, et al. (1987) A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J Virol 61(1):218-20 |
| abstractText | Mus musculus subsp. musculus (Czech II) mammary tumor DNA frequently contains an integrated proviral genome of the mouse mammary tumor virus (MMTV) within a specific 0.5-kilobase-pair region of the cellular genome (designated int-3). Viral integration at this site results in activation of expression of an adjacent cellular gene. We mapped int-3 to mouse chromosome 17 by analysis of PstI-restricted cellular DNAs from mouse-hamster somatic cell hybrids. Restriction analysis of cellular DNA from (C3H/OuJ X Czech II) X Czech II backcross mice established the gene order T-H-2-int-3. These results demonstrated that the int-3 locus is distinct from two other common integration regions for mouse mammary tumor virus (designated int-1 and int-2) in mammary tumor DNA and suggest that several cellular genes may be at risk for virally induced activation during mammary tumor development. |
