| First Author | Höglund P | Year | 1988 |
| Journal | J Exp Med | Volume | 168 |
| Issue | 4 | Pages | 1469-74 |
| PubMed ID | 3171481 | Mgi Jnum | J:275380 |
| Mgi Id | MGI:6304372 | Doi | 10.1084/jem.168.4.1469 |
| Citation | Hoglund P, et al. (1988) Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice. J Exp Med 168(4):1469-74 |
| abstractText | The H-2Dd transgenic strain D8 on C57BL background was more resistant to subcutaneous challenge of RBL-5 lymphoma cells than B6 controls. The direct role of the H-2Dd antigen was investigated by the use of (D8 x B6)F1 crosses and (D8 B6) x B6 backcrosses. The latter showed cosegregation with regard to Dd antigen expression and lymphoma resistance, both of which were inherited in a pattern consistent with control by a single dominant gene. The rejection potential in (D8 x B6)F1 mice appeared as strong as that seen in crosses between B6 and MHC congenic mice (on B10 background) carrying H-2Dd. The lymphoma resistance could be abrogated by treatment with anti-asialo GM1 antiserum or anti-NK 1.1 mAb, indicating a role for NK cells. |
