| Primary Identifier | MGI:2141920 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 101543 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Predicted to act upstream of or within miRNA-mediated post-transcriptional gene silencing. Predicted to be located in anchoring junction; cytoplasm; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in P-body; adherens junction; and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human WTIP (WT1 interacting protein). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit complete preimplantation lethality. Heterozygotes are viable with no evidence of proteinuria or glomerular pathology but show increased susceptibility to glomerular injury in response to lipopolysaccharide or adriamycin treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
