| First Author | Goebbels S | Year | 2017 |
| Journal | Nat Neurosci | Volume | 20 |
| Issue | 1 | Pages | 10-15 |
| PubMed ID | 27775720 | Mgi Jnum | J:239698 |
| Mgi Id | MGI:5829514 | Doi | 10.1038/nn.4425 |
| Citation | Goebbels S, et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci 20(1):10-15 |
| abstractText | The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination. |
