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Protein Coding Gene : Rif1 replication timing regulatory factor 1
Primary Identifier  MGI:1098622 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  51869
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Involved in regulation of nucleobase-containing compound metabolic process and telomere organization. Acts upstream of or within cellular response to leukemia inhibitory factor and somatic stem cell population maintenance. Located in chromosome and pronucleus. Part of chromatin. Is active in chromosome, telomeric repeat region. Is expressed in several structures, including early conceptus; hindgut epithelium; primordial germ cell; reproductive system; and urinary system. Orthologous to human RIF1 (replication timing regulatory factor 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation. [provided by MGI curators]
  • synonyms:
  • MGI:2139383,
  • AW549474,
  • Rif1,
  • MGI:2139159,
  • RIKEN cDNA 5730435J01 gene,
  • AU016181,
  • DNA segment, Chr 2, ERATO Doi 145, expressed,
  • 5730435J01Rik,
  • D2Ertd145e,
  • MGI:1922959,
  • RIKEN cDNA 6530403D07 gene,
  • 6530403D07Rik,
  • expressed sequence AW549474,
  • replication timing regulatory factor 1,
  • expressed sequence AU016181,
  • MGI:1923494
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