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Publication : Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice.

First Author  Cestari V Year  1992
Journal  Behav Neural Biol Volume  58
Issue  1 Pages  58-63
PubMed ID  1358055 Mgi Jnum  J:2211
Mgi Id  MGI:50735 Doi  10.1016/0163-1047(92)90922-q
Citation  Cestari V, et al. (1992) Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice. Behav Neural Biol 58(1):58-63
abstractText  Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (-)-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance.
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