| Type | disruption phenotype | Description | Mice are apparently healthy and show no developmental defects nor gross abnormality of glucose or lipid metabolism. However, they display a significant elevation of plasma HDL cholesterol and phospholipid levels. They also show a modest increase of APOA1, plus a number of mild gender- or diet-specific lipid metabolism phenotypes (PubMed:23554939). Deletion in bone marrow-derived cells, including macrophages, reduces atherosclerotic lesion progression (PubMed:25347070). |
