First Author | Piccolo S | Year | 2013 |
Journal | Cancer Res | Volume | 73 |
Issue | 16 | Pages | 4978-81 |
PubMed ID | 23913939 | Mgi Jnum | J:202524 |
Mgi Id | MGI:5519981 | Doi | 10.1158/0008-5472.CAN-13-0962 |
Citation | Piccolo S, et al. (2013) p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer. Cancer Res 73(16):4978-81 |
abstractText | Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. |