| Primary Identifier | IPR012502 | Type | Domain |
| Short Name | WAPL_dom |
| description | The D. melanogaster WAPL protein regulates heterochromatin structure []. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation is limited to a third of the protein sequence, a WAPL homologue has been identified in mammals. Mammalian WAPL may play a significant role in meiosis as does the Drosophila one. Human WAPL is overexpressed in invasive human cervical cancers and is often associated with cervical carcinogenesis [, ].This entry represents a domain found in the WAPL proteins. |
