| Primary Identifier | IPR039874 | Type | Family |
| Short Name | WAPL |
| description | Wings apart-like protein (WAPL) regulates heterochromatin structure []. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV) []. hWAPL (), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein []. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death []. |
