| First Author | Bignell E | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 8 | Pages | 5204-7 |
| PubMed ID | 16041040 | Mgi Jnum | J:100419 |
| Mgi Id | MGI:3588470 | Doi | 10.1128/IAI.73.8.5204-5207.2005 |
| Citation | Bignell E, et al. (2005) Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun 73(8):5204-7 |
| abstractText | While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47(phox)(-/-) murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47(phox)(-/-) mice. |
