| First Author | Yasukawa K | Year | 1998 |
| Journal | Biol Pharm Bull | Volume | 21 |
| Issue | 10 | Pages | 1072-6 |
| PubMed ID | 9821812 | Mgi Jnum | J:52742 |
| Mgi Id | MGI:1330100 | Doi | 10.1248/bpb.21.1072 |
| Citation | Yasukawa K, et al. (1998) Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 21(10):1072-6 |
| abstractText | Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a]anthracene-initiated mice. |
