| First Author | Hevner RF | Year | 2001 |
| Journal | Neuron | Volume | 29 |
| Issue | 2 | Pages | 353-66 |
| PubMed ID | 11239428 | Mgi Jnum | J:70189 |
| Mgi Id | MGI:2136552 | Doi | 10.1016/s0896-6273(01)00211-2 |
| Citation | Hevner RF, et al. (2001) Tbr1 regulates differentiation of the preplate and layer 6. Neuron 29(2):353-66 |
| abstractText | During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. |
