| First Author | Adamski FM | Year | 2000 |
| Journal | Mol Immunol | Volume | 37 |
| Issue | 8 | Pages | 435-44 |
| PubMed ID | 11090878 | Mgi Jnum | J:66154 |
| Mgi Id | MGI:1928038 | Doi | 10.1016/s0161-5890(00)00065-1 |
| Citation | Adamski FM, et al. (2000) Expression of the Fc receptor in the mammary gland during lactation in the marsupial trichosurus vulpecula (brushtail possum). Mol Immunol 37(8):435-44 |
| abstractText | One of several functions described for the Fc receptor is regulation of IgG isotype transport into milk. The first marsupial homologues of the Fc receptor heavy and light chains, FcRn and beta-2 microglobulin, from the brushtail possum have been cloned and characterised. The level of FcRn mRNA in the possum mammary gland was highest at the start of lactation, and decreased slowly thereafter. Expression of FcRn mRNA did not increase during the switch phase when the concentration of IgG in milk is highest. In contrast, the level of beta-2 microglobulin mRNA in the mammary gland increased during the switch phase when milk IgG concentration also increases. This correlation between beta-2 microglobulin mRNA expression in the mammary gland with the time of active IgG-transfer into milk was also observed in the bovine and murine mammary gland. This suggests that expression of the Fc receptor in the mammary gland is controlled by the expression of beta-2 microglobulin and that its expression is upregulated during the period of highest IgG-transfer into milk. |
