| Primary Identifier | IPR028268 | Type | Family |
| Short Name | Pianissimo_fam |
| description | Protein pianissimo (PiaA) is a component of the target of rapamycin complex 2 (TORC2) in Dictyostelium []. This complex regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Homologues of PiaA are found in Saccharomyces cerevisiae (TSC11/AVO3) [], Schizosaccaromyces pombe (Ste20) [], and vertebrates, where it is also known as Rictor (rapamycin-insensitive companion of mTOR) [, ].Rictor, together with Sin1, is believed to function as an adaptor protein controlling the mTORC2 substrate binding and specificity. Rictor is known to have a role in cytoskeleton regulation and cell migration [, ]. It is likely that rictor regulates cell morphology and migration by playing a role as the indispensable component of mTORC2 and also by carrying mTORC2-independent functions. |
