| First Author | Takikawa O | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 226 |
| Issue | 1 | Pages | 247-53 |
| PubMed ID | 8806622 | Mgi Jnum | J:35255 |
| Mgi Id | MGI:82707 | Doi | 10.1006/bbrc.1996.1341 |
| Citation | Takikawa O, et al. (1996) Multiple expression of Ly-6C and accumulation of a Ly-6C pre-mRNA in activated macrophages involved in rejection of an allografted tumor. Biochem Biophys Res Commun 226(1):247-53 |
| abstractText | We established a monoclonal antibody against a surface antigen of activated macrophages (Mos) involved in the rejection of an allografted mouse tumor, Meth A. Bacteria-elicited Mos also expressed the antigen but resident or inflammatory Mos, or other leukocytes, did not. The antigen was identified as Ly-6C by isolation of cDNA clones encoding it. Two-dimensional immunoblotting revealed that Ly-6C of the Mos exists in multiple forms with a similar size but with different isoelectric points. A Ly-6C pre-mRNA also accumulated abundantly in the Mos. Thus, the multiple expression of Ly-6C and the accumulation of the pre-mRNA are the features of allograft- and bacteria-elicited Mos. |
