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Comment :

Type  MGI:General Description  1 of 31 (3.2%) and 4 of 27 (15%) transgenic mice developed acute premyelocytic leukemia (APML) by 12 and 24 months of age, respectively the average latency to APML onset is 7.5 +/- 0.8 months the proportion of early myeloid-lineage cells is elevated in peripheral blood of transgenic mice with leukemia an abnormal population of Gr-1+ CD34+ cells is present in bone marrow and blood of transgenic mice with leukemia and accounts for a large proportion (34% and 45% in 2 animals) of leukemic spleen cells; histologic examination shows this population is enriched for immature myeloid cells spleen cells from transgenic mice with leukemia transmit APML resulting in death of 100% of unirradiated, syngeneic (C3H xC57BL/6)F1 mice culture of spleen cells from leukemic mice in the presence of all trans retinoic acid (ATRA) significantly increases the proportion of histologically identified late myeloid cells relative to those in untreated cultures