| First Author | Aizawa H | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5655 | Pages | 197-202 |
| PubMed ID | 14716005 | Mgi Jnum | J:87443 |
| Mgi Id | MGI:2687130 | Doi | 10.1126/science.1089845 |
| Citation | Aizawa H, et al. (2004) Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science 303(5655):197-202 |
| abstractText | The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis. |
