| First Author | van Zeijl CJ | Year | 2010 |
| Journal | Mol Cell Endocrinol | Volume | 321 |
| Issue | 2 | Pages | 231-8 |
| PubMed ID | 20223276 | Mgi Jnum | J:159992 |
| Mgi Id | MGI:4453244 | Doi | 10.1016/j.mce.2010.03.002 |
| Citation | van Zeijl CJ, et al. (2010) Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice. Mol Cell Endocrinol 321(2):231-8 |
| abstractText | The heterodimer thyrostimulin, comprised of two novel glycoprotein hormone subunits GPA2 and GPB5, activates the TSH receptor. To understand its role in the regulation of the hypothalamus-pituitary-thyroid (HPT-) axis, we evaluated juvenile and adult GPB5 knock-out (GPB5(-/-)) and wild type mice (WT) during euthyroidism, hypothyroidism and thyrotoxicosis. Surprisingly, juvenile euthyroid GPB5(-/-) mice displayed marked hypothyroxinemia (25% lower serum T(4), unchanged TSH) and also during thyrotoxicosis juvenile GPB5(-/-) mice had 25% lower serum T(4), compared to WT. During hypothyroidism, despite similar serum T(4), pituitary TSHbeta mRNA was 2-fold lower in GPB5(-/-) mice compared to WT. Adult mice displayed increased pituitary deiodinase type 2 during euthyroidism and decreased serum T(4) during hypothyroidism in GPB5(-/-). Thus, lacking GPB5 results in moderate deviations of the HPT-axis. The more pronounced differences observed in juvenile mice compared to adult mice are in agreement with the notion that GPB5 has a role during development. |
