| Primary Identifier | MGI:1341865 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 17169 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction; negative regulation of hippo signaling; and negative regulation of protein localization to nucleus. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). PHENOTYPE: Homozygous disruption of this gene results in decreased body weight, increased energy expenditure, reduced adiposity, and protection from high-fat diet induced obesity. On a high-fat diet, mice show resistance to hepatic steatosis, improved glucose tolerance, and decreased insulin levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
