| Primary Identifier | IPR038783 | Type | Family |
| Short Name | MAPK_Sty1/Hog1 |
| description | This family is composed of the mitogen-activated protein kinases (MAPKs) Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar fungal proteins. Sty1 and Hog1 are stress-activated MAPKs that participate in transcriptional regulation in response to stress [].Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation [, ]. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3 []. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmental stress response [, ].Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription []. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1 []. |
