| First Author | Willott JF | Year | 1995 |
| Journal | Behav Neurosci | Volume | 109 |
| Issue | 3 | Pages | 396-403 |
| PubMed ID | 7662150 | Mgi Jnum | J:26823 |
| Mgi Id | MGI:74254 | Doi | 10.1037//0735-7044.109.3.396 |
| Citation | Willott JF, et al. (1995) Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition. Behav Neurosci 109(3):396-403 |
| abstractText | Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice with high-frequency hearing loss. With a 2-ms ISI, 5-month-old C57 mice (but not the normal-hearing mice) exhibited pronounced prepulse augmentation (PPA) of startle: Amplitudes were much larger when S1 was present. Prepulse inhibition (PPI) occurred with ISIs of 10-100 ms in all subject groups. With long ISIs of 200 and 500 ms, however, PPI was strong only in 5-month-old C57 mice and only with S1 frequencies of 8, 12, and 16 kHz. Physiological studies of neural plasticity have shown that frequencies of 8-16 kHz become over-represented (more neurons responding) in the central auditory system of C57 mice, suggesting a link with prolonged PPI observed here. |
