| First Author | García-García MJ | Year | 2008 |
| Journal | Development | Volume | 135 |
| Issue | 18 | Pages | 3053-62 |
| PubMed ID | 18701545 | Mgi Jnum | J:139139 |
| Mgi Id | MGI:3807361 | Doi | 10.1242/dev.022897 |
| Citation | Garcia-Garcia MJ, et al. (2008) Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development 135(18):3053-62 |
| abstractText | In Xenopus and zebrafish embryos, elongation of the anterior-posterior body axis depends on convergent extension, a process that involves polarized cell movements and is regulated by non-canonical Wnt signaling. The mechanisms that control axis elongation of the mouse embryo are much less well understood. Here, we characterize the ENU-induced mouse mutation chato, which causes arrest at midgestation and defects characteristic of convergent extension mutants, including a shortened body axis, mediolaterally extended somites and an open neural tube. The chato mutation disrupts Zfp568, a Kruppel-associated box (KRAB) domain zinc-finger protein. Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes cell rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body axis elongation in all embryonic tissues through a process independent of non-canonical Wnt signaling. |
