| First Author | Schiffer SG | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 216 |
| Issue | 1 | Pages | 170-6 |
| PubMed ID | 7488084 | Mgi Jnum | J:29645 |
| Mgi Id | MGI:77170 | Doi | 10.1006/bbrc.1995.2606 |
| Citation | Schiffer SG, et al. (1995) An alternately spliced mRNA encoding functional domains of murine MAdCAM-1. Biochem Biophys Res Commun 216(1):170-6 |
| abstractText | cDNA clones representing a small (0.8 kb) form of murine mucosal addressin cell adhesion molecule-1 (MAdCAM-1) mRNA were obtained and sequenced. The sequence was identical to the published 1.6 kb murine MAdCAM-1 cDNA sequence, except that 432 nucleotides encoding the mucin-like and IgA-homologous portions were deleted. This cDNA most likely represents an alternately spliced mRNA. Substantial amounts of both the short and long MAdCAM-1 mRNAs are present in murine mesenteric lymph node. Ig fusion proteins displaying either the short or long forms of MAdCAM-1 can bind Mn(++)-activated JY cells bearing human alpha 4 beta 7 integrin, indicating that the two N-terminal Ig-like domains of MAdCAM-1 are sufficient to bind its integrin counter-receptor. |
