First Author | Gridley T | Year | 1991 |
Journal | Genomics | Volume | 11 |
Issue | 3 | Pages | 501-7 |
PubMed ID | 1837787 | Mgi Jnum | J:11579 |
Mgi Id | MGI:59990 | Doi | 10.1016/0888-7543(91)90056-k |
Citation | Gridley T, et al. (1991) The murine Mov-34 gene: full-length cDNA and genomic organization. Genomics 11(3):501-7 |
abstractText | The Mov-34 mutation is a recessive embryonic lethal mutation caused by experimental introduction of a recombinant Moloney murine leukemia provirus into the mouse germline. We have cloned a full-length cDNA from the Mov-34 gene, the transcription unit disrupted by the proviral integration. This cDNA is predicted to encode a novel 321-amino acid, 36-kDa protein of unknown function. Overlapping phage lambda clones containing the entire Mov-34 gene have been isolated. The Mov-34 gene spans just over 8 kb and contains seven exons. The 5' flanking region of the Mov-34 gene contains neither TATA nor CAAT box sequences, and 5' end mapping by primer extension and ribonuclease protection reveal multiple transcription initiation sites. |