| Primary Identifier | MGI:87929 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 11532 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; response to lipopolysaccharide; and response to nitrosative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). PHENOTYPE: Homozygous null mutants are viable with increased S-nitrosothiols in RBCs, increased susceptibility to various toxins, and abnormal blood pressure regulation under anesthesia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
