| First Author | O'Connor MA | Year | 2014 |
| Journal | J Virol | Volume | 88 |
| Issue | 4 | Pages | 2349-53 |
| PubMed ID | 24335302 | Mgi Jnum | J:205492 |
| Mgi Id | MGI:5545670 | Doi | 10.1128/JVI.02960-13 |
| Citation | O'Connor MA, et al. (2014) Use of IRF-3 and/or IRF-7 Knockout Mice To Study Viral Pathogenesis: Lessons from a Murine Retrovirus-Induced AIDS Model. J Virol 88(4):2349-53 |
| abstractText | Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences. |
