| First Author | Jay DC | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 6 | Pages | e67363 |
| PubMed ID | 23840678 | Mgi Jnum | J:225051 |
| Mgi Id | MGI:5691454 | Doi | 10.1371/journal.pone.0067363 |
| Citation | Jay DC, et al. (2013) Bim mediates the elimination of functionally unfit Th1 responders from the memory pool. PLoS One 8(6):e67363 |
| abstractText | Selective clonal deletion in the CD4(+) T cell compartment during the transition from effector to memory is accompanied by enhanced expression of the pro-apoptotic Bcl-2 family member Bim. Here, we show that Bim deficiency enables the survival of poorly functional Th1 responders that are normally eliminated during contraction. However, rescued bim(-/-) CD4(+) "memory" T cells continued to demonstrate deficient effector functions, poor sensitivity to antigen and an inability to respond to secondary challenge. Our results demonstrate that Bim activity plays a key role in shaping the CD4(+) memory T cell repertoire, ensuring the emergence of highly functional CD4(+) memory T cells and the elimination of Th1 effector cells with sub-optimal function. We propose that Bim is a key mediator of T cell death in the absence of appropriate TCR-driven activation and differentiation. |
