| Primary Identifier | MGI:108063 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 20438 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including identical protein binding activity; ubiquitin conjugating enzyme binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of intrinsic apoptotic signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein destabilization. Predicted to be located in cytosol; early endosome; and nucleus. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1). PHENOTYPE: Primary mouse embryonic fibroblasts hemizygous for a targeted allele show no apparent alterations in Trp53-mediated responses or mitotic progression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
