| Primary Identifier | MGI:1922997 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 75747 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; regulation of signal transduction; and response to insulin. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex. Is expressed in brain; cortical plate; and embryo. Orthologous to human SESN3 (sestrin 3). PHENOTYPE: When fed a high fat diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptake, increased hepatic steatosis, and decreased mitochondria in the liver. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
