| First Author | Wimmer N | Year | 2013 |
| Journal | Mol Immunol | Volume | 54 |
| Issue | 1 | Pages | 40-7 |
| PubMed ID | 23220069 | Mgi Jnum | J:191053 |
| Mgi Id | MGI:5460903 | Doi | 10.1016/j.molimm.2012.10.036 |
| Citation | Wimmer N, et al. (2013) Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30alpha in a TRAF3-dependent manner. Mol Immunol 54(1):40-7 |
| abstractText | Our earlier studies indicated that activation of the lymphotoxin beta receptor (LTbetaR) by T cell derived LTalpha(1)beta(2) regulates inflammatory cytokine expression. While characterizing the cellular and molecular mechanisms responsible for the down regulation of the inflammatory reaction after LTbetaR stimulation we were able to identify the specific induction of TRIM30alpha expression as a result of LTbetaR signalling in mouse macrophages. Furthermore, we could demonstrate that LTbetaR activation in these cells results in the down regulation of pro-inflammatory cytokine (e.g. TNF and IL-6) and mediator expression upon TLR4 and TLR9 re-stimulation, demonstrating that LTbetaR activation on mouse macrophages dampens pro-inflammatory cytokine and mediator expression. Thus, LTbetaR signalling renders macrophages hypo-responsive to subsequent stimulation with TLR ligands. The observation of an LTbetaR-mediated TLR-tolerance in the human monocyte cell line THP-1 suggests that similar signalling mechanisms seem to exist in human cells. Signalling pathway analysis clearly demonstrated that LTbetaR-induced TRIM30alpha expression is mediated by an IkappaBalpha-dependent signalling pathway. Furthermore, the LTbetaR-induced TRIM30alpha expression seems to be TRAF3 dependent. Our data suggest that LTbetaR activation on mouse macrophages is involved in the control of pro-inflammatory cytokine and mediator expression by activation of a signalling pathway that controls exacerbating inflammatory cytokine production. |
