| First Author | Zörnig M | Year | 1996 |
| Journal | Oncogene | Volume | 12 |
| Issue | 8 | Pages | 1789-801 |
| PubMed ID | 8622900 | Mgi Jnum | J:32921 |
| Mgi Id | MGI:80408 | Citation | Zornig M, et al. (1996) Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2. Oncogene 12(8):1789-801 |
| abstractText | The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy, To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double transgenic mice, We find accelerated tumour formation in infected animals and show that the gfi-1 gene and neighbouring loci on mouse chromosome 5 are occupied by proviruses in about 53% of the tumours leading in all cases to high level gfi-1 expression. In agreement with data from Gilks et al, (1993) we find that forced expression of the gfi-1 encoded zinc finger protein in IL-2 dependent T-cells provokes increased survival upon IL-2 depletion and we present evidence that this occurs at least in part through stimulation of proliferation, Our data suggest that gfi-1 is a proto-oncogene and very efficiently engages in a tripartite oncogene cooperation with both mye and pim-1 genes in T-cell lymphomagenesis. |
