| First Author | Allen JD | Year | 1997 |
| Journal | Oncogene | Volume | 15 |
| Issue | 10 | Pages | 1133-41 |
| PubMed ID | 9294606 | Mgi Jnum | J:42922 |
| Mgi Id | MGI:1096744 | Doi | 10.1038/sj.onc.1201288 |
| Citation | Allen JD, et al. (1997) Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene 15(10):1133-41 |
| abstractText | Evidence from proviral tagging experiments has suggested that pim-2 is similar in oncogenic behavior to its well characterized relative pim-1. While the basal expression in tissues differs, both genes are highly expressed in mitogenically stimulated hematopoietic cells and their transcription is induced in response to the same cytokines. Expression of a pim-2 transgene in lymphoid cells predisposed mice to T-cell lymphomas like those promoted by pim-1 transgenes. Moreover, strong collaboration with an E mu-myc transgene was manifested as pre-B cell leukemia in neonate bi-transgenic animals. Remarkably, this collaboration was attenuated but not prevented by X-inactivation of one of the transgenes. The addition of pim-2 to the fold increases the prominence of the pim proto-oncogene family in tumorigenesis. |
