| First Author | Brancho D | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 9 | Pages | 3670-81 |
| PubMed ID | 15831472 | Mgi Jnum | J:97631 |
| Mgi Id | MGI:3575961 | Doi | 10.1128/MCB.25.9.3670-3681.2005 |
| Citation | Brancho D, et al. (2005) Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades. Mol Cell Biol 25(9):3670-81 |
| abstractText | Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-kappaB pathway and the extracellular signal-regulated kinase, c-Jun NH(2)-terminal kinase (JNK), and p38 MAP kinase pathways. Here, we examined the effect of targeted disruption of the murine Mlk3 gene. Mlk3(-/-) mice were found to be viable and healthy. Primary embryonic fibroblasts prepared from these mice exhibited no major signaling defects. However, we did find that MLK3 deficiency caused a selective reduction in tumor necrosis factor (TNF)-stimulated JNK activation. Together, these data demonstrate that MLK3 contributes to the TNF signaling pathway that activates JNK. |
