| Primary Identifier | MGI:2429943 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 229898 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including G protein activity; GTP binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of innate immune response; and response to bacterium. Acts upstream of or within cellular response to type II interferon and response to bacterium. Located in cytoplasmic vesicle. Is active in symbiont cell surface. Orthologous to human GBP5 (guanylate binding protein 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to Listeria infection and NLRP3 inflammation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
