| First Author | Nagata S | Year | 1995 |
| Journal | Science | Volume | 267 |
| Issue | 5203 | Pages | 1449-56 |
| PubMed ID | 7533326 | Mgi Jnum | J:23794 |
| Mgi Id | MGI:71483 | Doi | 10.1126/science.7533326 |
| Citation | Nagata S, et al. (1995) The Fas death factor. Science 267(5203):1449-56 |
| abstractText | Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction. |
