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Publication : Neural BC1 RNA in mouse skeletal muscle is a denervation-induced RNA whose expression is developmentally regulated.

First Author  Anzai K Year  1996
Journal  Neurosci Lett Volume  216
Issue  2 Pages  81-4
PubMed ID  8904788 Mgi Jnum  J:36534
Mgi Id  MGI:83962 Doi  10.1016/0304-3940(96)12981-5
Citation  Anzai K, et al. (1996) Neural BC1 RNA in mouse skeletal muscle is a denervation-induced RNA whose expression is developmentally regulated. Neurosci Lett 216(2):81-4
abstractText  We detected neural BC1 RNA in mouse skeletal muscle. The level of BC1 RNA was high in the fetus, but it declined progressively to the adult level as development proceeded. These observations suggest that this RNA is involved in the prenatal development and differentiation of muscles. Although its developmental expression correlates with the fetal period of polyneuronal innervation, BC1 RNA does not seem to play a direct role(s) in synaptogenesis, since its expression was not restricted to the neuromuscular junction. We also demonstrated that the BC1 RNA level in adult muscle was elevated after denervation, suggesting that changes in the activity of muscles or neural factors caused by axotomy, or both may result in BC1 RNA upregulation.
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