| Primary Identifier | IPR027323 | Type | Family |
| Short Name | MAP4 |
| description | Microtubule-associated protein 4 (MAP4) is a non-neuronal microtubule-associated protein that promotes microtubule assembly [, ]. It contains a microtubule binding domain (Tau/MAP repeats) that shares homology with neuronal microtubule-associated protein MAP2 and Tau []. It is a ubiquitous heat-stable MAP responsible for stabilisation of microtubules []. Overexpression of MAP4 causes a shift of tubulin dimers to a polymerised fraction and formed dense, stable microtubule networks []. The persistent transcriptional up-regulation of MAP4, cardiac alpha- and beta-tubulinis is linked to the cytoskeletal abnormality during severe pressure overload-induced cardiac hypertrophy []. |
