| First Author | Takada T | Year | 2003 |
| Journal | Genome Res | Volume | 13 |
| Issue | 4 | Pages | 589-600 |
| PubMed ID | 12671000 | Mgi Jnum | J:82851 |
| Mgi Id | MGI:2655863 | Doi | 10.1101/gr.975303 |
| Citation | Takada T, et al. (2003) Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex. Genome Res 13(4):589-600 |
| abstractText | We have determined the complete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility complex (Mhc) from strain 129/Sv (haplotype bc). The sequence contains 26 genes. The sequence spans from the last 50 kb of the H2-T region, including 2 class I genes and 3 class I pseudogenes, and includes the H2-M region up to Gabbr1. A 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two subfamilies, M1 and M10, distinct from other mouse class I genes. This M1/M10 class I gene-cluster is separated from the centromeric H2-T and the telomeric H2-M4, -5 and -6 class I genes by 'nonclass I genes'. Comparison with the corresponding 853-kb region of the human Mhc, which includes the HLA-A region, shows a mosaic of conserved regions of orthologous nonclass I genes separated by regions of species-specific expansion of paralogous Mhc class I genes. The analysis of this mosaic structure illuminates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the framework hypothesis. |
